Conformal coverage of liver tumors by the thermal coagulation zone in 2450-MHz microwave ablation

• Main Authors: Hongjian Gao, Xiaoru Wang, Shuicai Wu, Zhuhuang Zhou, Yanping Bai, Weiwei Wu
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2019-01-01
• Series: International Journal of Hyperthermia
• Subjects: conformal coverage; three-dimensional reconstruction; microwave ablation; coagulation zone; treatment planning; liver tumor
• Online Access: http://dx.doi.org/10.1080/02656736.2019.1617437
• ISSN: 0265-6736; 1464-5157

Purpose: To optimize treatment schemes using 2450-MHz microwave ablation (MWA), a novel conformal coverage method based on bipolar-angle mapping is proposed that determines whether a liver tumor is completely encompassed by thermal coagulation zones. Materials and methods: Firstly, three-dimensional (3-D) triangular mesh data of liver tumors were reconstructed from clinical computed tomography (CT) slices using the Marching cubes (MC) algorithm. Secondly, characterization models of thermal coagulation zones were established based on finite element simulation results of 40, 45, 50, 55, and 60 W ablations. Finally, coagulation zone models and tumor surface data were mapped and fused on a two-dimensional (2-D) plane to achieve conformal coverage of liver tumors by comparing the corresponding polar radii. Results: Optimal parameters for ablation treatment of liver tumors were efficiently obtained with the proposed conformal coverage method. Fifteen liver tumors were obtained with maximal diameters of 12.329–78.612 mm (mean ± standard deviation, 39.094 ± 19.447 mm). The insertion positions and orientations of the MWA antenna were determined based on 3-D reconstruction results of these tumors. The ablation patterns and durations of tumors were planned according to the minimum mean standard deviations between the ablative margin and tumor surface. Conclusion: The proposed method can be applied to computer-assisted MWA treatment planning of liver tumors, and is expected to guide clinical procedures in future.