Exosomes and Obesity-Related Insulin Resistance

Exosomes are extracellular vesicles, delivering signal molecules from donor cells to recipient cells. The cargo of exosomes, including proteins, DNA and RNA, can target the recipient tissues and organs, which have an important role in disease development. Insulin resistance is a kind of pathological...

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Main Authors:	Li-Min Lei, Xiao Lin, Feng Xu, Su-Kang Shan, Bei Guo, Fu-Xing-Zi Li, Ming-Hui Zheng, Yi Wang, Qiu-Shuang Xu, Ling-Qing Yuan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	exosomes insulin resistance obesity inflammation mesenchymal stem cell
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.651996/full

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spelling	doaj-f825ae4f96d64e62b106605ea480d3002021-03-18T08:14:26ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-03-01910.3389/fcell.2021.651996651996Exosomes and Obesity-Related Insulin ResistanceLi-Min Lei0Xiao Lin1Feng Xu2Su-Kang Shan3Bei Guo4Fu-Xing-Zi Li5Ming-Hui Zheng6Yi Wang7Qiu-Shuang Xu8Ling-Qing Yuan9National Clinical Research Center for Metabolic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Metabolic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Metabolic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Metabolic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Metabolic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Metabolic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Metabolic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Metabolic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Metabolic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, ChinaExosomes are extracellular vesicles, delivering signal molecules from donor cells to recipient cells. The cargo of exosomes, including proteins, DNA and RNA, can target the recipient tissues and organs, which have an important role in disease development. Insulin resistance is a kind of pathological state, which is important in the pathogeneses of type 2 diabetes mellitus (T2DM), gestational diabetes mellitus and Alzheimer’s disease. Furthermore, obesity is a kind of inducement of insulin resistance. In this review, we summarized recent research advances on exosomes and insulin resistance, especially focusing on obesity-related insulin resistance. These studies suggest that exosomes have great importance in the development of insulin resistance in obesity and have great potential for use in the diagnosis and therapy of insulin resistance.https://www.frontiersin.org/articles/10.3389/fcell.2021.651996/fullexosomesinsulin resistanceobesityinflammationmesenchymal stem cell
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Li-Min Lei Xiao Lin Feng Xu Su-Kang Shan Bei Guo Fu-Xing-Zi Li Ming-Hui Zheng Yi Wang Qiu-Shuang Xu Ling-Qing Yuan
spellingShingle	Li-Min Lei Xiao Lin Feng Xu Su-Kang Shan Bei Guo Fu-Xing-Zi Li Ming-Hui Zheng Yi Wang Qiu-Shuang Xu Ling-Qing Yuan Exosomes and Obesity-Related Insulin Resistance Frontiers in Cell and Developmental Biology exosomes insulin resistance obesity inflammation mesenchymal stem cell
author_facet	Li-Min Lei Xiao Lin Feng Xu Su-Kang Shan Bei Guo Fu-Xing-Zi Li Ming-Hui Zheng Yi Wang Qiu-Shuang Xu Ling-Qing Yuan
author_sort	Li-Min Lei
title	Exosomes and Obesity-Related Insulin Resistance
title_short	Exosomes and Obesity-Related Insulin Resistance
title_full	Exosomes and Obesity-Related Insulin Resistance
title_fullStr	Exosomes and Obesity-Related Insulin Resistance
title_full_unstemmed	Exosomes and Obesity-Related Insulin Resistance
title_sort	exosomes and obesity-related insulin resistance
publisher	Frontiers Media S.A.
series	Frontiers in Cell and Developmental Biology
issn	2296-634X
publishDate	2021-03-01
description	Exosomes are extracellular vesicles, delivering signal molecules from donor cells to recipient cells. The cargo of exosomes, including proteins, DNA and RNA, can target the recipient tissues and organs, which have an important role in disease development. Insulin resistance is a kind of pathological state, which is important in the pathogeneses of type 2 diabetes mellitus (T2DM), gestational diabetes mellitus and Alzheimer’s disease. Furthermore, obesity is a kind of inducement of insulin resistance. In this review, we summarized recent research advances on exosomes and insulin resistance, especially focusing on obesity-related insulin resistance. These studies suggest that exosomes have great importance in the development of insulin resistance in obesity and have great potential for use in the diagnosis and therapy of insulin resistance.
topic	exosomes insulin resistance obesity inflammation mesenchymal stem cell
url	https://www.frontiersin.org/articles/10.3389/fcell.2021.651996/full
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Exosomes and Obesity-Related Insulin Resistance

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