Graphene Oxide Hybridized nHAC/PLGA Scaffolds Facilitate the Proliferation of MC3T3-E1 Cells

• Main Authors: Chunyong Liang, Yongchao Luo, Guodong Yang, Dan Xia, Lei Liu, Xiaomin Zhang, Hongshui Wang
• Format: Article
• Language: English
• Published: SpringerOpen 2018-01-01
• Series: Nanoscale Research Letters
• Subjects: Graphene oxide; Poly(lactic-co-glycolic acid); Collagen; Nano-hydroxyapatite; Biodegradable porous scaffold; Bone tissue engineering
• Online Access: http://link.springer.com/article/10.1186/s11671-018-2432-6
• ISSN: 1931-7573; 1556-276X

Abstract Biodegradable porous biomaterial scaffolds play a critical role in bone regeneration. In this study, the porous nano-hydroxyapatite/collagen/poly(lactic-co-glycolic acid)/graphene oxide (nHAC/PLGA/GO) composite scaffolds containing different amount of GO were fabricated by freeze-drying method. The results show that the synthesized scaffolds possess a three-dimensional porous structure. GO slightly improves the hydrophilicity of the scaffolds and reinforces their mechanical strength. Young’s modulus of the 1.5 wt% GO incorporated scaffold is greatly increased compared to the control sample. The in vitro experiments show that the nHAC/PLGA/GO (1.5 wt%) scaffolds significantly cell adhesion and proliferation of osteoblast cells (MC3T3-E1). This present study indicates that the nHAC/PLGA/GO scaffolds have excellent cytocompatibility and bone regeneration ability, thus it has high potential to be used as scaffolds in the field of bone tissue engineering.