Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient

Currently adopted diagnostic flow charts consider transthyretin and light-chain cardiac amyloidosis as mutually exclusive. Here, we report for the first time, to our knowledge, the demonstration of a biopsy-proven dual pathology in an 80-year-old man with sequential development of both wild-type tra...

Full description

Bibliographic Details
Main Authors:	Giuseppe Vergaro, MD, PhD, Vincenzo Castiglione, MD, Roberta Poletti, MD, Gabriele Buda, MD, Angela Pucci, MD, PhD, Veronica Musetti, BSc, Dario Genovesi, MD, Alberto Aimo, MD, Claudio Passino, MD, Michele Emdin, MD, PhD
Format:	Article
Language:	English
Published:	Elsevier 2021-03-01
Series:	JACC: Case Reports
Subjects:	AL amyloidosis ATTR amyloidosis cardiac amyloidosis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666084921001261

id	doaj-f81ec105412b48f880409702ecf8c02d
record_format	Article
spelling	doaj-f81ec105412b48f880409702ecf8c02d2021-06-07T07:06:53ZengElsevierJACC: Case Reports2666-08492021-03-0133450454Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same PatientGiuseppe Vergaro, MD, PhD0Vincenzo Castiglione, MD1Roberta Poletti, MD2Gabriele Buda, MD3Angela Pucci, MD, PhD4Veronica Musetti, BSc5Dario Genovesi, MD6Alberto Aimo, MD7Claudio Passino, MD8Michele Emdin, MD, PhD9Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy; Fondazione Toscana Gabriele Monasterio, Pisa, Italy; Address for correspondence: Dr. Giuseppe Vergaro, Scuola Superiore Sant’Anna and Fondazione Toscana Gabriele Monasterio, Via G. Moruzzi 1, 56124 Pisa, Italy.Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, ItalyFondazione Toscana Gabriele Monasterio, Pisa, ItalyHematology Department, University of Pisa, Pisa, ItalyHistopathology Department, University of Pisa, Pisa, ItalyFondazione Toscana Gabriele Monasterio, Pisa, ItalyFondazione Toscana Gabriele Monasterio, Pisa, ItalyInstitute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, ItalyInstitute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy; Fondazione Toscana Gabriele Monasterio, Pisa, ItalyInstitute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy; Fondazione Toscana Gabriele Monasterio, Pisa, ItalyCurrently adopted diagnostic flow charts consider transthyretin and light-chain cardiac amyloidosis as mutually exclusive. Here, we report for the first time, to our knowledge, the demonstration of a biopsy-proven dual pathology in an 80-year-old man with sequential development of both wild-type transthyretin amyloidosis and light-chain cardiac amyloidosis cardiomyopathy over a 3-year timespan. (Level of Difficulty: Intermediate.)http://www.sciencedirect.com/science/article/pii/S2666084921001261AL amyloidosisATTR amyloidosiscardiac amyloidosis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Giuseppe Vergaro, MD, PhD Vincenzo Castiglione, MD Roberta Poletti, MD Gabriele Buda, MD Angela Pucci, MD, PhD Veronica Musetti, BSc Dario Genovesi, MD Alberto Aimo, MD Claudio Passino, MD Michele Emdin, MD, PhD
spellingShingle	Giuseppe Vergaro, MD, PhD Vincenzo Castiglione, MD Roberta Poletti, MD Gabriele Buda, MD Angela Pucci, MD, PhD Veronica Musetti, BSc Dario Genovesi, MD Alberto Aimo, MD Claudio Passino, MD Michele Emdin, MD, PhD Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient JACC: Case Reports AL amyloidosis ATTR amyloidosis cardiac amyloidosis
author_facet	Giuseppe Vergaro, MD, PhD Vincenzo Castiglione, MD Roberta Poletti, MD Gabriele Buda, MD Angela Pucci, MD, PhD Veronica Musetti, BSc Dario Genovesi, MD Alberto Aimo, MD Claudio Passino, MD Michele Emdin, MD, PhD
author_sort	Giuseppe Vergaro, MD, PhD
title	Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient
title_short	Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient
title_full	Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient
title_fullStr	Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient
title_full_unstemmed	Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient
title_sort	biopsy evidence of sequential transthyretin and immunoglobulin light-chain cardiac amyloidosis in the same patient
publisher	Elsevier
series	JACC: Case Reports
issn	2666-0849
publishDate	2021-03-01
description	Currently adopted diagnostic flow charts consider transthyretin and light-chain cardiac amyloidosis as mutually exclusive. Here, we report for the first time, to our knowledge, the demonstration of a biopsy-proven dual pathology in an 80-year-old man with sequential development of both wild-type transthyretin amyloidosis and light-chain cardiac amyloidosis cardiomyopathy over a 3-year timespan. (Level of Difficulty: Intermediate.)
topic	AL amyloidosis ATTR amyloidosis cardiac amyloidosis
url	http://www.sciencedirect.com/science/article/pii/S2666084921001261
work_keys_str_mv	AT giuseppevergaromdphd biopsyevidenceofsequentialtransthyretinandimmunoglobulinlightchaincardiacamyloidosisinthesamepatient AT vincenzocastiglionemd biopsyevidenceofsequentialtransthyretinandimmunoglobulinlightchaincardiacamyloidosisinthesamepatient AT robertapolettimd biopsyevidenceofsequentialtransthyretinandimmunoglobulinlightchaincardiacamyloidosisinthesamepatient AT gabrielebudamd biopsyevidenceofsequentialtransthyretinandimmunoglobulinlightchaincardiacamyloidosisinthesamepatient AT angelapuccimdphd biopsyevidenceofsequentialtransthyretinandimmunoglobulinlightchaincardiacamyloidosisinthesamepatient AT veronicamusettibsc biopsyevidenceofsequentialtransthyretinandimmunoglobulinlightchaincardiacamyloidosisinthesamepatient AT dariogenovesimd biopsyevidenceofsequentialtransthyretinandimmunoglobulinlightchaincardiacamyloidosisinthesamepatient AT albertoaimomd biopsyevidenceofsequentialtransthyretinandimmunoglobulinlightchaincardiacamyloidosisinthesamepatient AT claudiopassinomd biopsyevidenceofsequentialtransthyretinandimmunoglobulinlightchaincardiacamyloidosisinthesamepatient AT micheleemdinmdphd biopsyevidenceofsequentialtransthyretinandimmunoglobulinlightchaincardiacamyloidosisinthesamepatient
_version_	1721391664334897152

Biopsy Evidence of Sequential Transthyretin and Immunoglobulin Light-Chain Cardiac Amyloidosis in the Same Patient

Similar Items