Unfractionated and Low Molecular Weight Heparin Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells

Unfractionated and Low Molecular Weight Heparin Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells

The interaction with platelets is of crucial importance for tumor cells passing through hematogenous metastasis. Platelets protect cancer cells from immune surveillance and exhibit many other prometastatic effects. Notably, platelets can change the epithelial tumor phenotype, a process termed epithe...

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Bibliographic Details
Main Authors: Jan Moritz Ponert, Lukas Maria Gockel, Svenja Henze, Martin Schlesinger
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
heparin
platelet
tumor
epithelial-mesenchymal transition
EMT
cancer stem cells
enoxaparin
Online Access:http://www.mdpi.com/1420-3049/23/10/2690

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