Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs

Drug delivery systems have opened new avenues to improve the therapeutic effects of already-efficient molecules. Particularly, Solid Lipid Nanoparticles (SLNs) have emerged as promising nanocarriers in cancer therapy. SLNs offer remarkable advantages such as low toxicity, high bioavailability of dru...

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Main Authors: Laura Bayón-Cordero, Itziar Alkorta, Lide Arana
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Nanomaterials
Subjects:
Online Access:https://www.mdpi.com/2079-4991/9/3/474
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spelling doaj-f8113c8d755348dca59b4fdc6790b8002020-11-25T00:50:21ZengMDPI AGNanomaterials2079-49912019-03-019347410.3390/nano9030474nano9030474Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer DrugsLaura Bayón-Cordero0Itziar Alkorta1Lide Arana2Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Barrio Sarriena S/N, 48940 Leioa, SpainBiochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Barrio Sarriena S/N, 48940 Leioa, SpainBiochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Barrio Sarriena S/N, 48940 Leioa, SpainDrug delivery systems have opened new avenues to improve the therapeutic effects of already-efficient molecules. Particularly, Solid Lipid Nanoparticles (SLNs) have emerged as promising nanocarriers in cancer therapy. SLNs offer remarkable advantages such as low toxicity, high bioavailability of drugs, versatility of incorporation of hydrophilic and lipophilic drugs, and feasibility of large-scale production. Their molecular structure is crucial to obtain high quality SLN preparations and it is determined by the relationship between the composition and preparation method. Additionally, SLNs allow overcoming several physiological barriers that hinder drug delivery to tumors and are also able to escape multidrug resistance mechanisms, characteristic of cancer cells. Focusing on cell delivery, SLNs can improve drug delivery to target cells by different mechanisms, such as passive mechanisms that take advantage of the tumor microenvironment, active mechanisms by surface modification of SLNs, and codelivery mechanisms. SLNs can incorporate many different drugs and have proven to be effective in different types of tumors (i.e., breast, lung, colon, liver, and brain), corroborating their potential. Finally, it has to be taken into account that there are still some challenges to face in the application of SLNs in anticancer treatments but their possibilities seem to be high.https://www.mdpi.com/2079-4991/9/3/474solid lipid nanoparticlesdrug deliverycancertumorchemotherapy
collection DOAJ
language English
format Article
sources DOAJ
author Laura Bayón-Cordero
Itziar Alkorta
Lide Arana
spellingShingle Laura Bayón-Cordero
Itziar Alkorta
Lide Arana
Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs
Nanomaterials
solid lipid nanoparticles
drug delivery
cancer
tumor
chemotherapy
author_facet Laura Bayón-Cordero
Itziar Alkorta
Lide Arana
author_sort Laura Bayón-Cordero
title Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs
title_short Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs
title_full Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs
title_fullStr Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs
title_full_unstemmed Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs
title_sort application of solid lipid nanoparticles to improve the efficiency of anticancer drugs
publisher MDPI AG
series Nanomaterials
issn 2079-4991
publishDate 2019-03-01
description Drug delivery systems have opened new avenues to improve the therapeutic effects of already-efficient molecules. Particularly, Solid Lipid Nanoparticles (SLNs) have emerged as promising nanocarriers in cancer therapy. SLNs offer remarkable advantages such as low toxicity, high bioavailability of drugs, versatility of incorporation of hydrophilic and lipophilic drugs, and feasibility of large-scale production. Their molecular structure is crucial to obtain high quality SLN preparations and it is determined by the relationship between the composition and preparation method. Additionally, SLNs allow overcoming several physiological barriers that hinder drug delivery to tumors and are also able to escape multidrug resistance mechanisms, characteristic of cancer cells. Focusing on cell delivery, SLNs can improve drug delivery to target cells by different mechanisms, such as passive mechanisms that take advantage of the tumor microenvironment, active mechanisms by surface modification of SLNs, and codelivery mechanisms. SLNs can incorporate many different drugs and have proven to be effective in different types of tumors (i.e., breast, lung, colon, liver, and brain), corroborating their potential. Finally, it has to be taken into account that there are still some challenges to face in the application of SLNs in anticancer treatments but their possibilities seem to be high.
topic solid lipid nanoparticles
drug delivery
cancer
tumor
chemotherapy
url https://www.mdpi.com/2079-4991/9/3/474
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