Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains.

There is widespread concern that H5N1 avian influenza A viruses will emerge as a pandemic threat, if they become capable of human-to-human (H2H) transmission. Avian strains lack this capability, which suggests that it requires important adaptive mutations. We performed a large-scale comparative anal...

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Bibliographic Details
Main Authors: Olivo Miotto, A T Heiny, Randy Albrecht, Adolfo García-Sastre, Tin Wee Tan, J Thomas August, Vladimir Brusic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2815782?pdf=render