An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells

An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells

ABSTRACT Human pluripotent stem cells (hPSCs) are an important system to study early human development, model human diseases, and develop cell replacement therapies. However, genetic manipulation of hPSCs is challenging and a method to simultaneously activate multiple genomic sites in a controllable...

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Bibliographic Details
Main Authors: Jianying Guo, Dacheng Ma, Rujin Huang, Jia Ming, Min Ye, Kehkooi Kee, Zhen Xie, Jie Na
Format: Article
Language:English
Published: SpringerOpen 2017-01-01
Series:Protein & Cell
Subjects:
CRISPR
transcription activation
human pluripotent stem cells
NANOG
pluripotency
Online Access:http://link.springer.com/article/10.1007/s13238-016-0360-8

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