Role of Autoimmune Responses in Periodontal Disease

Periodontal diseases are characterized by localized infections and inflammatory conditions that directly affect teeth supporting structures which are the major cause of tooth loss. Several studies have demonstrated the involvement of autoimmune responses in periodontal disease. Evidences of involvem...

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Main Authors: Soumya Nair, Mohamed Faizuddin, Jayanthi Dharmapalan
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Autoimmune Diseases
Online Access:http://dx.doi.org/10.1155/2014/596824
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spelling doaj-f7fe5b0d6ba64968847936ff28e9c4082020-11-25T02:30:41ZengHindawi LimitedAutoimmune Diseases2090-04222090-04302014-01-01201410.1155/2014/596824596824Role of Autoimmune Responses in Periodontal DiseaseSoumya Nair0Mohamed Faizuddin1Jayanthi Dharmapalan2Om Dental Clinic, No. 1554, Hebbal 2nd Stage, Mysore 570017, IndiaM.R. Ambedkar Dental College and Hospital, No. 1/37, Cline Road, Cooke Town, Bangalore 560005, IndiaM.R. Ambedkar Dental College and Hospital, No. 1/37, Cline Road, Cooke Town, Bangalore 560005, IndiaPeriodontal diseases are characterized by localized infections and inflammatory conditions that directly affect teeth supporting structures which are the major cause of tooth loss. Several studies have demonstrated the involvement of autoimmune responses in periodontal disease. Evidences of involvement of immunopathology have been reported in periodontal disease. Bacteria in the dental plaque induce antibody formation. Autoreactive T cells, natural killer cells, ANCA, heat shock proteins, autoantibodies, and genetic factors are reported to have an important role in the autoimmune component of periodontal disease. The present review describes the involvement of autoimmune responses in periodontal diseases and also the mechanisms underlying these responses. This review is an attempt to throw light on the etiopathogenesis of periodontal disease highlighting the autoimmunity aspect of the etiopathogenesis involved in the initiation and progression of the disease. However, further clinical trials are required to strengthen the role of autoimmunity as a cause of periodontal disease.http://dx.doi.org/10.1155/2014/596824
collection DOAJ
language English
format Article
sources DOAJ
author Soumya Nair
Mohamed Faizuddin
Jayanthi Dharmapalan
spellingShingle Soumya Nair
Mohamed Faizuddin
Jayanthi Dharmapalan
Role of Autoimmune Responses in Periodontal Disease
Autoimmune Diseases
author_facet Soumya Nair
Mohamed Faizuddin
Jayanthi Dharmapalan
author_sort Soumya Nair
title Role of Autoimmune Responses in Periodontal Disease
title_short Role of Autoimmune Responses in Periodontal Disease
title_full Role of Autoimmune Responses in Periodontal Disease
title_fullStr Role of Autoimmune Responses in Periodontal Disease
title_full_unstemmed Role of Autoimmune Responses in Periodontal Disease
title_sort role of autoimmune responses in periodontal disease
publisher Hindawi Limited
series Autoimmune Diseases
issn 2090-0422
2090-0430
publishDate 2014-01-01
description Periodontal diseases are characterized by localized infections and inflammatory conditions that directly affect teeth supporting structures which are the major cause of tooth loss. Several studies have demonstrated the involvement of autoimmune responses in periodontal disease. Evidences of involvement of immunopathology have been reported in periodontal disease. Bacteria in the dental plaque induce antibody formation. Autoreactive T cells, natural killer cells, ANCA, heat shock proteins, autoantibodies, and genetic factors are reported to have an important role in the autoimmune component of periodontal disease. The present review describes the involvement of autoimmune responses in periodontal diseases and also the mechanisms underlying these responses. This review is an attempt to throw light on the etiopathogenesis of periodontal disease highlighting the autoimmunity aspect of the etiopathogenesis involved in the initiation and progression of the disease. However, further clinical trials are required to strengthen the role of autoimmunity as a cause of periodontal disease.
url http://dx.doi.org/10.1155/2014/596824
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AT jayanthidharmapalan roleofautoimmuneresponsesinperiodontaldisease
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