Assessment of short-term trauma degree as well as long-term survival and recurrence between endoscopic resection and radical resection treatment of early gastric cancer

• Main Authors: Qi Pan, Zheng Zhang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-10-01
• Series: Journal of Hainan Medical University
• Subjects: Early gastric cancer; Endoscopic resection; Recurrence; Tumor markers; Red blood cell immune function
• Online Access: http://www.hnykdxxb.com/PDF/201620/19.pdf

Objective: To compare the short-term trauma degree as well as long-term survival and recurrence between endoscopic resection and radical resection treatment of early gastric cancer. Methods: A total of 187 patients diagnosed with early gastric cancer in our hospital from October 2008 to May 2011 were retrospectively analyzed and divided into endoscopic group and laparotomy group according to different operation methods. 5-year survival rate and recurrence rate of two groups of patients were followed up, trauma-related molecules and tumor markers in serum as well as red blood cell immune function-related indexes in peripheral blood were determined 3 d after operation, and serum tumor markers were determined 1 year after operation. Results: Within the 5 years of follow-up, there were no death cases in both groups and the survival rate reached 100%, and the 3-year recurrence rate and 5-year recurrence rate of endoscopic group were not significantly different from those of laparotomy group; 3 d after operation, serum CA199, CA724, OPN, CD44v6, DKK-1, CRP, PA and SAA levels of endoscopic group were significantly lower than those of laparotomy group while GAS and MTL levels in serum as well as C3bR rosette number, ICR rosette number, CD58, CD59 and CR3 fluorescence intensity in peripheral blood red blood cells were significantly higher than those of laparotomy group; 1 year after operation, serum CA199, CA724, OPN, CD44v6 and DKK-1 levels were not significantly different between two groups of patients. Conclusion: Endoscopic resection treatment of early gastric cancer is with equivalent long-term curative effect to open radical resection and weaker short-term trauma degree than laparotomy, and causes less suppression on postoperative gastrointestinal function and red blood cell immune function.