Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis

Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis

Double-positive disease, defined by double-seropositivity for serum anti-glomerular basement membrane (GBM) antibodies and anti-neutrophil cytoplasmic antibodies (ANCA) is a rare cause of pulmonary-renal syndrome. Here, we present an exceptional course of a 20-year-old male with seropositivity for a...

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Main Authors: Fares T Rajah, Ali A Alhabobi, Noura M Aloudah, Ayumun I Osman, Elwaleed A Elhassan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Saudi Journal of Kidney Diseases and Transplantation
Online Access:http://www.sjkdt.org/article.asp?issn=1319-2442;year=2021;volume=32;issue=1;spage=240;epage=244;aulast=Rajah
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spelling doaj-f7fd8de9f7ee4be695275cd52f5f6e4b2021-07-07T14:41:50ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422021-01-0132124024410.4103/1319-2442.318532Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated VasculitisFares T RajahAli A AlhabobiNoura M AloudahAyumun I OsmanElwaleed A ElhassanDouble-positive disease, defined by double-seropositivity for serum anti-glomerular basement membrane (GBM) antibodies and anti-neutrophil cytoplasmic antibodies (ANCA) is a rare cause of pulmonary-renal syndrome. Here, we present an exceptional course of a 20-year-old male with seropositivity for anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies and anti-GBM antibody, who presented first with renal impairment due to focal necrotizing crescentic glomerulonephritis. After receiving treatment, he presented two years later with a relapse manifesting with diffuse alveolar hemorrhage and multiple splenic infarcts. We discuss the clinical presentation patterns and treatment strategies of this entity.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2021;volume=32;issue=1;spage=240;epage=244;aulast=Rajah
collection DOAJ
language English
format Article
sources DOAJ
author Fares T Rajah
Ali A Alhabobi
Noura M Aloudah
Ayumun I Osman
Elwaleed A Elhassan
spellingShingle Fares T Rajah
Ali A Alhabobi
Noura M Aloudah
Ayumun I Osman
Elwaleed A Elhassan
Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis
Saudi Journal of Kidney Diseases and Transplantation
author_facet Fares T Rajah
Ali A Alhabobi
Noura M Aloudah
Ayumun I Osman
Elwaleed A Elhassan
author_sort Fares T Rajah
title Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis
title_short Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis
title_full Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis
title_fullStr Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis
title_full_unstemmed Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis
title_sort splenic infarcts and pulmonary renal syndrome in a young patient with double-positive anti-gbm and anca-associated vasculitis
publisher Wolters Kluwer Medknow Publications
series Saudi Journal of Kidney Diseases and Transplantation
issn 1319-2442
publishDate 2021-01-01
description Double-positive disease, defined by double-seropositivity for serum anti-glomerular basement membrane (GBM) antibodies and anti-neutrophil cytoplasmic antibodies (ANCA) is a rare cause of pulmonary-renal syndrome. Here, we present an exceptional course of a 20-year-old male with seropositivity for anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies and anti-GBM antibody, who presented first with renal impairment due to focal necrotizing crescentic glomerulonephritis. After receiving treatment, he presented two years later with a relapse manifesting with diffuse alveolar hemorrhage and multiple splenic infarcts. We discuss the clinical presentation patterns and treatment strategies of this entity.
url http://www.sjkdt.org/article.asp?issn=1319-2442;year=2021;volume=32;issue=1;spage=240;epage=244;aulast=Rajah
work_keys_str_mv AT farestrajah splenicinfarctsandpulmonaryrenalsyndromeinayoungpatientwithdoublepositiveantigbmandancaassociatedvasculitis
AT aliaalhabobi splenicinfarctsandpulmonaryrenalsyndromeinayoungpatientwithdoublepositiveantigbmandancaassociatedvasculitis
AT nouramaloudah splenicinfarctsandpulmonaryrenalsyndromeinayoungpatientwithdoublepositiveantigbmandancaassociatedvasculitis
AT ayumuniosman splenicinfarctsandpulmonaryrenalsyndromeinayoungpatientwithdoublepositiveantigbmandancaassociatedvasculitis
AT elwaleedaelhassan splenicinfarctsandpulmonaryrenalsyndromeinayoungpatientwithdoublepositiveantigbmandancaassociatedvasculitis
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