CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway.

CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway.

The regulatory mechanisms governing the cell cycle progression of hematopoietic stem cells (HSCs) are well characterized, but those responsible for the return of proliferating HSCs to a quiescent state remain largely unknown. Here, we present evidence that CD81, a tetraspanin molecule acutely respon...

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Bibliographic Details
Main Authors: Kuanyin K Lin, Lara Rossi, Nathan C Boles, Brian E Hall, Thaddeus C George, Margaret A Goodell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3172193?pdf=render

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