Life Extension Factor Klotho Enhances Cognition

Life Extension Factor Klotho Enhances Cognition

Aging is the primary risk factor for cognitive decline, an emerging health threat to aging societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive decline is unknown. We show that a lifespan-extending variant of the human KLOTHO gene, KL-VS, is associated with enhance...

Full description

Bibliographic Details
Main Authors:	Dena B. Dubal, Jennifer S. Yokoyama, Lei Zhu, Lauren Broestl, Kurtresha Worden, Dan Wang, Virginia E. Sturm, Daniel Kim, Eric Klein, Gui-Qiu Yu, Kaitlyn Ho, Kirsten E. Eilertson, Lei Yu, Makoto Kuro-o, Philip L. De Jager, Giovanni Coppola, Gary W. Small, David A. Bennett, Joel H. Kramer, Carmela R. Abraham, Bruce L. Miller, Lennart Mucke
Format:	Article
Language:	English
Published:	Elsevier 2014-05-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124714002873

Similar Items

Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?
by: Dubal Dena B, et al.
Published: (2012-11-01)

Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System
by: Makoto Kuro-o
Published: (2018-01-01)

Sugar sweetened beverage consumption is positively associated with Klotho levels at two years of age in LatinX youth
by: Sofia Villagomez, et al.
Published: (2021-04-01)

Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice
by: Julio Leon, et al.
Published: (2017-08-01)

Effect of Klotho on HTR-8/SVneo cells invasion
by: Xiao-Lei Xue, et al.
Published: (2019-05-01)

Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
by: Julie A Harris, et al.
Published: (2012-01-01)

Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients
by: Naoko Otani-Takei, et al.
Published: (2015-01-01)

Klotho Regulates 14-3-3ζ Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress.
by: Reynolds K Brobey, et al.
Published: (2015-01-01)

Klotho Exerts an Emerging Role in Cytokinesis
by: Chiao-Yin Sun, et al.
Published: (2020-09-01)

Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice
by: Christina B. Leibrock, et al.
Published: (2016-02-01)

Klotho, Aging, and the Failing Kidney
by: Sarah Buchanan, et al.
Published: (2020-08-01)

Klotho and the Treatment of Human Malignancies
by: Aishani Sachdeva, et al.
Published: (2020-06-01)

Klotho, stem cells, and aging
by: Bian A, et al.
Published: (2015-08-01)

The role of klotho in systemic sclerosis
by: R. Talotta, et al.
Published: (2017-12-01)

The role of Klotho in CKD progression
by: Núria Alexandra Lopes Figueiredo de Carvalho Paulo
Published: (2021)

FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
by: Kathleen R. Markan, et al.
Published: (2017-06-01)

Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions
by: Ryuichi Watanabe, et al.
Published: (2017-08-01)

Skeletal muscle as a regulator of the longevity protein, Klotho
by: Keith G Avin, et al.
Published: (2014-06-01)

Klotho: An emerging factor in neurodegenerative diseases
by: Gauri V Pathare, et al.
Published: (2019-01-01)

The Organ Handling of Soluble Klotho in Humans
by: Daniela Picciotto, et al.
Published: (2019-08-01)

The role of klotho in chronic kidney disease
by: Di Zou, et al.
Published: (2018-10-01)

Measurement of Serum Klotho in Systemic Sclerosis
by: Rossella Talotta, et al.
Published: (2017-01-01)

Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease
by: Akimoto Tetsu, et al.
Published: (2012-11-01)

Efeitos da proteína Klotho sobre a sinalização de insulina e metabolismo energético no sistema nervoso central.
by: Mazucanti, Caio Henrique Yokoyama
Published: (2018)

Fibroblast growth factor-23 (FGF-23) / soluble Klotho protein (sKlotho) / sclerostin glycoprotein ratio disturbance is a novel risk factor for cardiovascular complications in ESRD patients receiving treatment with regular hemodialysis or hemodiafiltration
by: L Yu Milovanova, et al.
Published: (2018-06-01)

Circulating α-Klotho Levels in Hemodialysis Patients and Their Relationship to Atherosclerosis
by: Ling Yu, et al.
Published: (2018-07-01)

The Role of Klotho During Embryonic Gastrulation in Zebrafish
by: Kang-Chieh Lo, et al.
Published: (2018)

Role of Klotho in Chronic Calcineurin Inhibitor Nephropathy
by: Kang Luo, et al.
Published: (2019-01-01)

New Insights into the Mechanism of Action of Soluble Klotho
by: George D. Dalton, et al.
Published: (2017-11-01)

Retinal Degeneration in a Klotho-overexpressing Mouse
by: Lee, Brittany Celeste
Published: (2006)

Alpha-Klotho as a regulator of calcium homeostasis
by: Tsuji, Yoshihito
Published: (2011)

Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways.
by: Reynolds K Brobey, et al.
Published: (2015-01-01)

Soluble Alpha-Klotho Alleviates Cardiac Fibrosis without Altering Cardiomyocytes Renewal
by: Wei-Yu Chen
Published: (2020-03-01)

Upregulation of the Creatine Transporter Slc6A8 by Klotho
by: Ahmad Almilaji, et al.
Published: (2014-11-01)

Transcription factor organic cation transporter 1 (OCT-1) affects the expression of porcine Klotho (KL) gene
by: Yan Li, et al.
Published: (2016-07-01)

α-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise
by: Zhijian Rao, et al.
Published: (2019-12-01)

Klotho inhibits neuronal senescence in human brain organoids
by: Mohammed R. Shaker, et al.
Published: (2021-08-01)

Serum Klotho Levels Contribute to the Prevention of Disease Progression
by: Nakanishi K, et al.
Published: (2021-01-01)

Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
by: Marlena Typiak, et al.
Published: (2021-01-01)

FGF-23, Klotho and Vitamin D Levels in Scleroderma
by: Ravan AHMADI, et al.
Published: (2017-04-01)