Prokineticin 2 Upregulation in the Peripheral Nervous System Has a Major Role in Triggering and Maintaining Neuropathic Pain in the Chronic Constriction Injury Model

Prokineticin 2 Upregulation in the Peripheral Nervous System Has a Major Role in Triggering and Maintaining Neuropathic Pain in the Chronic Constriction Injury Model

The new chemokine Prokineticin 2 (PROK2) and its receptors (PKR1 and PKR2) have a role in inflammatory pain and immunomodulation. Here we identified PROK2 as a critical mediator of neuropathic pain in the chronic constriction injury (CCI) of the sciatic nerve in mice and demonstrated that blocking t...

Full description

Bibliographic Details
Main Authors: Roberta Lattanzi, Daniela Maftei, Veronica Marconi, Fulvio Florenzano, Silvia Franchi, Elisa Borsani, Luigi Fabrizio Rodella, Gianfranco Balboni, Severo Salvadori, Paola Sacerdote, Lucia Negri
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/301292

Similar Items

Similar Items