IDO Inhibition Facilitates Antitumor Immunity of Vγ9Vδ2 T Cells in Triple-Negative Breast Cancer

IDO Inhibition Facilitates Antitumor Immunity of Vγ9Vδ2 T Cells in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) escape from immune-mediated destruction was associated with immunosuppressive responses that dampened the activation of tumor-infiltrating CD8 and γδ T cells. TNBC had a higher level of programmed cell death 1-ligand 1 (PD-L1) and indoleamine 2,3-dioxygenase (IDO...

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Bibliographic Details
Main Authors: Peng Li, Ruan Wu, Ke Li, Wenhui Yuan, Chuqian Zeng, Yuting Zhang, Xiao Wang, Xinhai Zhu, Jianjun Zhou, Ping Li, Yunfei Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
IDO
γδT cell
1-Methyl-L-tryptophan
perforin
anti-tumor immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.679517/full

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