Functionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens

Functionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens

The identification and tracking of antigen-specific immunoglobulin (Ig) sequences within total Ig repertoires is central to high-throughput sequencing (HTS) studies of infections or vaccinations. In this context, public Ig sequences shared by different individuals exposed to the same antigen could b...

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Bibliographic Details
Main Authors: Jean-Philippe Bürckert, Axel R. S. X. Dubois, William J. Faison, Sophie Farinelle, Emilie Charpentier, Regina Sinner, Anke Wienecke-Baldacchino, Claude P. Muller
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
transgenic rats
B cell repertoire
next-generation sequencing
repertoire convergence
public CDR3s
AIRR-seq
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01834/full

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