Anti-apoptotic and Immunomodulatory Effect of CB2 Agonist, JWH133, in a Neonatal Rat Model of Hypoxic-Ischemic Encephalopathy

Anti-apoptotic and Immunomodulatory Effect of CB2 Agonist, JWH133, in a Neonatal Rat Model of Hypoxic-Ischemic Encephalopathy

Introduction: Neonatal HIE is associated with high morbidity and mortality. Current research, is focused on developing alternative treatments to therapeutic hypothermia for treatment of HIE. The endocannabinoid system is known to be influential in neuronal protection. Activation of brain CB2 recepto...

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Bibliographic Details
Main Authors: Bhavna Gupta, Mary G. Hornick, Seema Briyal, Ramona Donovan, Preetha Prazad, Anil Gulati
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pediatrics
Subjects:
neonatal
encephalopathy
hypoxic ischemia
neuroprotection
CB2 agonist
Online Access:https://www.frontiersin.org/article/10.3389/fped.2020.00065/full

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