Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15382 |
| id |
doaj-f7c9d14db1d44c6a865877ade1d17933 |
|---|---|
| record_format |
Article |
| spelling |
doaj-f7c9d14db1d44c6a865877ade1d179332021-05-11T07:46:06ZengNature Publishing GroupNature Communications2041-17232017-05-01811810.1038/ncomms15382Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variantsLam C. Tsoi0Philip E. Stuart1Chao Tian2Johann E. Gudjonsson3Sayantan Das4Matthew Zawistowski5Eva Ellinghaus6Jonathan N. Barker7Vinod Chandran8Nick Dand9Kristina Callis Duffin10Charlotta Enerbäck11Tõnu Esko12Andre Franke13Dafna D. Gladman14Per Hoffmann15Külli Kingo16Sulev Kõks17Gerald G. Krueger18Henry W. Lim19Andres Metspalu20Ulrich Mrowietz21Sören Mucha22Proton Rahman23Andre Reis24Trilokraj Tejasvi25Richard Trembath26John J. Voorhees27Stephan Weidinger28Michael Weichenthal29Xiaoquan Wen30Nicholas Eriksson31Hyun M. Kang32David A. Hinds33Rajan P. Nair34Gonçalo R. Abecasis35James T Elder36Department of Dermatology, University of Michigan Medical SchoolDepartment of Dermatology, University of Michigan Medical School23andMe, Inc., Mountain ViewDepartment of Dermatology, University of Michigan Medical SchoolDepartment of Biostatistics, Center for Statistical Genetics, University of MichiganDepartment of Biostatistics, Center for Statistical Genetics, University of MichiganInstitute of Clinical Molecular Biology, Christian-Albrechts-University of KielDivision of Genetics and Molecular Medicine, St John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College LondonDepartment of Medicine, Division of Rheumatology, University of TorontoDivision of Genetics and Molecular Medicine, St John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College LondonDepartment of Dermatology, University of UtahDepartment of Dermatology, Linköping UniversityEstonian Genome Center, University of TartuInstitute of Clinical Molecular Biology, Christian-Albrechts-University of KielDepartment of Medicine, Division of Rheumatology, University of TorontoInstitute of Human Genetics, University of BonnDepartment of Dermatology and Venereology, Dermatology Clinic, Tartu University Hospital, University of TartuDepartment of Pathophysiology, Centre of Translational Medicine and Centre for Translational Genomics, University of TartuDepartment of Dermatology, University of UtahDepartment of Dermatology, Henry Ford HospitalEstonian Genome Center, University of TartuDepartment of Dermatology, University Medical Center Schleswig-Holstein, Campus KielInstitute of Clinical Molecular Biology, Christian-Albrechts-University of KielMemorial University, St. John'sInstitute of Human Genetics, FAU Erlangen-NürnbergDepartment of Dermatology, University of Michigan Medical SchoolDepartment of Medical and Molecular Genetics, King’s College LondonDepartment of Dermatology, University of Michigan Medical SchoolDepartment of Dermatology, University Medical Center Schleswig-Holstein, Campus KielDepartment of Dermatology, University Medical Center Schleswig-Holstein, Campus KielDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan23andMe, Inc., Mountain ViewDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan23andMe, Inc., Mountain ViewDepartment of Dermatology, University of Michigan Medical SchoolDepartment of Biostatistics, Center for Statistical Genetics, University of MichiganDepartment of Dermatology, University of Michigan Medical SchoolPsoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals.https://doi.org/10.1038/ncomms15382 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Lam C. Tsoi Philip E. Stuart Chao Tian Johann E. Gudjonsson Sayantan Das Matthew Zawistowski Eva Ellinghaus Jonathan N. Barker Vinod Chandran Nick Dand Kristina Callis Duffin Charlotta Enerbäck Tõnu Esko Andre Franke Dafna D. Gladman Per Hoffmann Külli Kingo Sulev Kõks Gerald G. Krueger Henry W. Lim Andres Metspalu Ulrich Mrowietz Sören Mucha Proton Rahman Andre Reis Trilokraj Tejasvi Richard Trembath John J. Voorhees Stephan Weidinger Michael Weichenthal Xiaoquan Wen Nicholas Eriksson Hyun M. Kang David A. Hinds Rajan P. Nair Gonçalo R. Abecasis James T Elder |
| spellingShingle |
Lam C. Tsoi Philip E. Stuart Chao Tian Johann E. Gudjonsson Sayantan Das Matthew Zawistowski Eva Ellinghaus Jonathan N. Barker Vinod Chandran Nick Dand Kristina Callis Duffin Charlotta Enerbäck Tõnu Esko Andre Franke Dafna D. Gladman Per Hoffmann Külli Kingo Sulev Kõks Gerald G. Krueger Henry W. Lim Andres Metspalu Ulrich Mrowietz Sören Mucha Proton Rahman Andre Reis Trilokraj Tejasvi Richard Trembath John J. Voorhees Stephan Weidinger Michael Weichenthal Xiaoquan Wen Nicholas Eriksson Hyun M. Kang David A. Hinds Rajan P. Nair Gonçalo R. Abecasis James T Elder Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants Nature Communications |
| author_facet |
Lam C. Tsoi Philip E. Stuart Chao Tian Johann E. Gudjonsson Sayantan Das Matthew Zawistowski Eva Ellinghaus Jonathan N. Barker Vinod Chandran Nick Dand Kristina Callis Duffin Charlotta Enerbäck Tõnu Esko Andre Franke Dafna D. Gladman Per Hoffmann Külli Kingo Sulev Kõks Gerald G. Krueger Henry W. Lim Andres Metspalu Ulrich Mrowietz Sören Mucha Proton Rahman Andre Reis Trilokraj Tejasvi Richard Trembath John J. Voorhees Stephan Weidinger Michael Weichenthal Xiaoquan Wen Nicholas Eriksson Hyun M. Kang David A. Hinds Rajan P. Nair Gonçalo R. Abecasis James T Elder |
| author_sort |
Lam C. Tsoi |
| title |
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| title_short |
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| title_full |
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| title_fullStr |
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| title_full_unstemmed |
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| title_sort |
large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-05-01 |
| description |
Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals. |
| url |
https://doi.org/10.1038/ncomms15382 |
| work_keys_str_mv |
AT lamctsoi largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT philipestuart largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT chaotian largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT johannegudjonsson largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT sayantandas largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT matthewzawistowski largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT evaellinghaus largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT jonathannbarker largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT vinodchandran largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT nickdand largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT kristinacallisduffin largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT charlottaenerback largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT tonuesko largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT andrefranke largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT dafnadgladman largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT perhoffmann largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT kullikingo largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT sulevkoks largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT geraldgkrueger largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT henrywlim largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT andresmetspalu largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT ulrichmrowietz largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT sorenmucha largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT protonrahman largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT andrereis largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT trilokrajtejasvi largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT richardtrembath largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT johnjvoorhees largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT stephanweidinger largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT michaelweichenthal largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT xiaoquanwen largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT nicholaseriksson largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT hyunmkang largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT davidahinds largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT rajanpnair largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT goncalorabecasis largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants AT jamestelder largescalemetaanalysischaracterizesgeneticarchitectureforcommonpsoriasisassociatedvariants |
| _version_ |
1721451708028026880 |