COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B

COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B

We investigated Nucleos(t)ide-analogue (NA)-resistance mutations (mt) in 142 treatment-naive children with Chronic Hepatitis B (CHB), using a sensitive co-amplification at lower denaturation temperature (COLD)-PCR with Sanger DNA sequencing. An NA resistance-associated mt in the hepatitis B virus (H...

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Bibliographic Details
Main Authors: Thuy Thi Bich Phung, Son Van Chu, Son Thien Vu, Hanh Thi Pham, Hang Minh Nguyen, Hoan Dang Nguyen, Ngan Thi Le, Dung Van Nguyen, Phuong Thai Truong, Van Thi Tuong Vu, Anh Thi Van Nguyen
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Diagnostics
Subjects:
COLD-PCR method
hepatitis B virus (HBV)
drug-resistance mutation
nucleos(t)ides analogues
treatment-naive children
Online Access:https://www.mdpi.com/2075-4418/10/7/491

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https://www.mdpi.com/2075-4418/10/7/491

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