Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition.

Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition.

Increasing evidence supports the central role of Paneth cells in maintaining intestinal host-microbial homeostasis. However, the direct impact of host genotype on Paneth cell function remains unclear. Here, we characterize key differences in Paneth cell function and intestinal microbial composition...

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Bibliographic Details
Main Authors: Ajay S Gulati, Michael T Shanahan, Janelle C Arthur, Emily Grossniklaus, Richard J von Furstenberg, Lieselotte Kreuk, Susan J Henning, Christian Jobin, R Balfour Sartor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3288091?pdf=render

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