Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
Detergents are indispensable reagents in membrane protein structural biology. Here, L. H. Urner and co-workers introduce oligoglycerol detergents (OGDs) and use native mass spectrometry to show how interactions of membrane proteins with native membrane lipids can be preserved during purification.
Bibliographic Details
| Main Authors: |
Leonhard H. Urner,
Idlir Liko,
Hsin-Yung Yen,
Kin-Kuan Hoi,
Jani Reddy Bolla,
Joseph Gault,
Fernando Gonçalves Almeida,
Marc-Philip Schweder,
Denis Shutin,
Svenja Ehrmann,
Rainer Haag,
Carol V. Robinson,
Kevin Pagel |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-14424-8
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