BMS-986020, a Specific LPA<sub>1</sub> Antagonist, Provides Neuroprotection against Ischemic Stroke in Mice

BMS-986020, a Specific LPA<sub>1</sub> Antagonist, Provides Neuroprotection against Ischemic Stroke in Mice

Stroke is a leading cause of death. Stroke survivors often suffer from long-term functional disability. This study demonstrated neuroprotective effects of BMS-986020 (BMS), a selective lysophosphatidic acid receptor 1 (LPA<sub>1</sub>) antagonist under clinical trials for lung fibrosis a...

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Bibliographic Details
Main Authors: Bhakta Prasad Gaire, Arjun Sapkota, Ji Woong Choi
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antioxidants
Subjects:
BMS-986020
transient middle cerebral artery occlusion (tMCAO)
neuroprotective effects
long-term neuroprotection
neurogenesis
angiogenesis
Online Access:https://www.mdpi.com/2076-3921/9/11/1097

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