The role of IL-6 gene (-174 C/G) polymorphism in patients with acute brucellosis

• Main Author: Elchin Huseynov Mammad oglu
• Format: Article
• Language: English
• Published: PC Technology Center 2018-12-01
• Series: ScienceRise: Medical Science
• Subjects: бруцельоз; цитокін; інтерлейкін-6; поліморфізм; ген; ступінь важкості; імунопатогенез; генотип; інтерлейкін-4; сприйнятливість
• Online Access: http://journals.uran.ua/sr_med/article/view/148880
• ISSN: 2519-478X; 2519-4798

The interrelationship of the IL-6 polymorphism (-174C/G) and susceptibility to brucellosis is well known. The aim: to determine the polymorphism of IL-6 (-174C/G) in patients with acute brucellosis Materials and methods. The article presents the results of a survey of 120 patients with acute brucellosis. The control group consisted of 30 healthy individuals. Patients of both groups are ethnic Azerbaijani who permanently reside in the Republic of Azerbaijan. The diagnosis of brucellosis was made on the basis of complaints, anamnesis, epidemiological and clinical data and the results of a specific study. Specific research methods were carried out by ELISA with the detection of IgM and IgG for brucella. In addition to the specific diagnostic data, the diagnosis of acute brucellosis took into account the duration of clinical symptoms up to 3 months after the first complaints appeared. All patients were tested for IL-6 polymorphism (-174C/G). The exclusion criteria for the study were age up to 18 years, confirmation of the diagnosis of subacute or chronic brucellosis, the presence of severe chronic comorbidity, which could significantly affect the reliability of the results. A detailed description of patients with brucellosis is presented. Among the surveyed individuals, men of young working age dominated. The criterion of severity was the following symptoms: fever, sweating, chills, headache, insomnia, low blood pressure, tachycardia, hepatosplenomegaly, levels of pro-inflammatory and anti-inflammatory cytokines. Results. Mild disease was established in 74 (61.7 %) people, while severe - only in 11 (9.1 %) patients. There were no statistically significant differences between different IL-6 genotypes between patients with brucellosis and healthy individuals. It was established that allele G was detected almost 3 times more often in patients with acute brucellosis compared to allele C. Conclusions. No statistically significant difference between different IL-6 genotypes (-174 C/G) in patients with brucellosis and healthy individuals was detected. The GC IL-6 genotype was significantly more often associated with severe brucellosis, while the GG genotype with mild