CHARACTERSTICS OF IMMUNE EFFECT OF BEMITHYL IN CHRONIC HEPATITIS

• Main Authors: S. V. Okovity, O. V. Ivanova, A. A. Boykova, N. M. Kalinina, N. I. Davydova, V. G. Radchenko, S. N. Shulenin
• Format: Article
• Language: Russian
• Published: SPb RAACI 2014-07-01
• Series: Medicinskaâ Immunologiâ
• Subjects: hepatitis; bemithyl; immunomodulatory action
• Online Access: https://www.mimmun.ru/mimmun/article/view/445

Abstract. Introduction of bemithyl into combined therapy of patients suffering chronic hepatitis allows toachieve a noticeable hepatoprotective effect. Apparently it is realized due to direct hepatotropic influence as well as through immunomodulatory action of the preparation directed at cellular immunity. At the same time, immunotropic action of bemithyl can be characterized as immunomodulatory one, which is confirmed by stimulation of T–cell immunity with some suppression of B–section and humoral immunity. An important factor of the immunotropic action of the drug is the absence of autoimmunization phenomena. Influence of bemithyl on macrophages section manifested by the decrease of liver tissue infiltration and simultaneous increase of blood monocyte count. At the same time, initial oxygen–dependent microbicidal activity of macrophages decreased a little, but stimulated indices increased. (Med. Immunol., 2005, vol.7, № 1, pp 93599)