Fetuin-A is also an adipokine

Fetuin-A is also an adipokine

Abstract Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of diabetes or cardiovascular diseases, we showed significant increases in both circulating and subcutaneous adipose tissue secreted Fet-A. Fu...

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Main Authors: Ishwarlal Jialal, Roma Pahwa
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Lipids in Health and Disease
Online Access:http://link.springer.com/article/10.1186/s12944-019-1021-8
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spelling doaj-f789d8e85b304ec189109793ee82109f2020-11-25T02:40:44ZengBMCLipids in Health and Disease1476-511X2019-03-011811210.1186/s12944-019-1021-8Fetuin-A is also an adipokineIshwarlal Jialal0Roma Pahwa1California North-state University College of MedicineNational Cancer Institute, NIHAbstract Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of diabetes or cardiovascular diseases, we showed significant increases in both circulating and subcutaneous adipose tissue secreted Fet-A. Furthermore we showed in mice models increase mRNA and protein following a high fat diet and in a model of metabolic syndrome. This work was recently confirmed by another group of investigators. Hence we propose that Fet-A be considered also as an adipokine.http://link.springer.com/article/10.1186/s12944-019-1021-8
collection DOAJ
language English
format Article
sources DOAJ
author Ishwarlal Jialal
Roma Pahwa
spellingShingle Ishwarlal Jialal
Roma Pahwa
Fetuin-A is also an adipokine
Lipids in Health and Disease
author_facet Ishwarlal Jialal
Roma Pahwa
author_sort Ishwarlal Jialal
title Fetuin-A is also an adipokine
title_short Fetuin-A is also an adipokine
title_full Fetuin-A is also an adipokine
title_fullStr Fetuin-A is also an adipokine
title_full_unstemmed Fetuin-A is also an adipokine
title_sort fetuin-a is also an adipokine
publisher BMC
series Lipids in Health and Disease
issn 1476-511X
publishDate 2019-03-01
description Abstract Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of diabetes or cardiovascular diseases, we showed significant increases in both circulating and subcutaneous adipose tissue secreted Fet-A. Furthermore we showed in mice models increase mRNA and protein following a high fat diet and in a model of metabolic syndrome. This work was recently confirmed by another group of investigators. Hence we propose that Fet-A be considered also as an adipokine.
url http://link.springer.com/article/10.1186/s12944-019-1021-8
work_keys_str_mv AT ishwarlaljialal fetuinaisalsoanadipokine
AT romapahwa fetuinaisalsoanadipokine
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