Anti-Oncogenic gem-Dihydroperoxides Induce Apoptosis in Cancer Cells by Trapping Reactive Oxygen Species

Anti-Oncogenic gem-Dihydroperoxides Induce Apoptosis in Cancer Cells by Trapping Reactive Oxygen Species

Organic gem-dihydroperoxides (DHPs) and their derived peroxides have attracted a great deal of attention as potential anti-cancer agents. However, the precise mechanism of their inhibitory effect on tumors is unknown. To determine the mechanism of the inhibitory effects of DHPs, we examined the effe...

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Bibliographic Details
Main Authors: Yuki Kuranaga, Nami Yamada, Maiko Kashiwaya, Moeko Nakamura, Lei Cui, Minami Kumazaki, Haruka Shinohara, Nobuhiko Sugito, Kohei Taniguchi, Yuko Ito, Tatsushi Nakayama, Bunji Uno, Akichika Itoh, Yukihiro Akao
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
ROS
dihydroperoxide
JNK/MAPK
cancer cell
Online Access:http://www.mdpi.com/1422-0067/17/1/71

Internet

http://www.mdpi.com/1422-0067/17/1/71

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