The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD.

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD.

INTRODUCTION:Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine associated with acute and chronic inflammatory disorders and corticosteroid insensitivity. Its expression in the airways of patients with chronic obstructive pulmonary disease (COPD), a relatively steroid insensiti...

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Main Authors: Kirsty E Russell, Kian Fan Chung, Colin J Clarke, Andrew L Durham, Patrick Mallia, Joseph Footitt, Sebastian L Johnston, Peter J Barnes, Simon R Hall, Karen D Simpson, Malcolm R Starkey, Philip M Hansbro, Ian M Adcock, Coen H Wiegman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4709227?pdf=render

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http://europepmc.org/articles/PMC4709227?pdf=render

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