Systemic Delivery of Tyrosine-Mutant AAV Vectors Results in Robust Transduction of Neurons in Adult Mice

Systemic Delivery of Tyrosine-Mutant AAV Vectors Results in Robust Transduction of Neurons in Adult Mice

Recombinant adeno-associated virus (AAV) vectors are powerful tools for both basic neuroscience experiments and clinical gene therapies for neurological diseases. Intravascularly administered self-complementary AAV9 vectors can cross the blood-brain barrier. However, AAV9 vectors are of limited usef...

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Bibliographic Details
Main Authors:	Asako Iida, Naomi Takino, Hitomi Miyauchi, Kuniko Shimazaki, Shin-ichi Muramatsu
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2013/974819

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