Activation of kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2/antioxidant response element pathway by curcumin enhances the anti-oxidative capacity of corneal endothelial cells

Activation of kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2/antioxidant response element pathway by curcumin enhances the anti-oxidative capacity of corneal endothelial cells

Fuchs endothelial corneal dystrophy is one of the most common indications for corneal transplantation, and impaired anti-oxidative function is observed in corneal endothelial cells (CECs). Curcumin is well-known for its anti-oxidative property; but, no study has examined the effect of curcumin on an...

Full description

Bibliographic Details
Main Authors:	Siao-Pei Guo, Hua-Ching Chang, Long-Sheng Lu, Der-Zen Liu, Tsung-Jen Wang
Format:	Article
Language:	English
Published:	Elsevier 2021-09-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Curcumin Corneal endothelial cells Reactive oxygen species (ROS) Kelch-like ECH-associated protein 1 (Keap1) Nuclear factor erythroid 2-related factor 2 (Nrf2) Antioxidant response element (ARE)
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332221006168

Similar Items

Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2)
by: Tian, Wang, et al.
Published: (2018)

The Keap1/Nrf2 Signaling Pathway in the Thyroid—2020 Update
by: Christina Thanas, et al.
Published: (2020-11-01)

Keap1/Nrf2 Signaling: A New Player in Thyroid Pathophysiology and Thyroid Cancer
by: Cedric O. Renaud, et al.
Published: (2019-08-01)

Nrf2 gene mutation and single nucleotide polymorphism rs6721961 of the Nrf2 promoter region in renal cell cancer
by: Yoshiyuki Yamaguchi, et al.
Published: (2019-11-01)

DNA Protecting Activities of Nymphaea nouchali (Burm. f) Flower Extract Attenuate t-BHP-Induced Oxidative Stress Cell Death through Nrf2-Mediated Induction of Heme Oxygenase-1 Expression by Activating MAP-Kinases
by: Md Badrul Alam, et al.
Published: (2017-09-01)

Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells
by: Noëmi Johanna Roos, et al.
Published: (2020-06-01)

Natural Nrf2 Modulators for Skin Protection
by: Yong Chool Boo
Published: (2020-09-01)

Upregulation of nuclear factor (erythroid-derived 2)-like 2 protein level in the human colorectal adenocarcinoma cell line DLD-1 by a heterocyclic organobismuth(III) compound
by: Katsuya Iuchi, et al.
Published: (2020-05-01)

Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines
by: Margaretha A. Skowron, et al.
Published: (2017-08-01)

Glutamine improves heat stress–induced oxidative damage in the broiler thigh muscle by activating the nuclear factor erythroid 2–related 2/Kelch-like ECH-associated protein 1 signaling pathway
by: Hong Hu, et al.
Published: (2020-03-01)

Zearalenone regulates key factors of the Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1–nuclear factor erythroid 2-related factor 2 signaling pathway in duodenum of post-weaning gilts
by: Qun Cheng, et al.
Published: (2021-08-01)

Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer
by: Yoshinobu Ichimura, et al.
Published: (2018-06-01)

Curcumin Inhibits Lipopolysaccharide-Induced Mucin 5AC Hypersecretion and Airway Inflammation via Nuclear Factor Erythroid 2-Related Factor 2
by: Xiao-Ping Lin, et al.
Published: (2018-01-01)

The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System
by: Dionysios V. Chartoumpekis, et al.
Published: (2020-09-01)

Comparative Cytotoxicity Study of PM2.5 and TSP Collected from Urban Areas
by: Ilseob Shim, et al.
Published: (2021-07-01)

Strange Bedfellows: Nuclear Factor, Erythroid 2-Like 2 (Nrf2) and Hypoxia-Inducible Factor 1 (HIF-1) in Tumor Hypoxia
by: Rachel K. Toth, et al.
Published: (2017-04-01)

Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications
by: Mahdie Rahban, et al.
Published: (2020-12-01)

Nrf2 Mediates Metabolic Reprogramming in Non-Small Cell Lung Cancer
by: Jiangang Zhao, et al.
Published: (2020-11-01)

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers
by: Das, M., et al.
Published: (2022)

Modulation of Keap1/Nrf2/ARE Signaling Pathway by Curcuma- and Garlic-Derived Hybrids
by: Melania Maria Serafini, et al.
Published: (2020-01-01)

Dietary arsenic supplementation induces oxidative stress by suppressing nuclear factor erythroid 2-related factor 2 in the livers and kidneys of laying hens
by: Yan Ma, et al.
Published: (2021-02-01)

Glycine increases glyoxalase‐1 function by promoting nuclear factor erythroid 2‐related factor 2 translocation into the nucleus of kidney cells of streptozotocin‐induced diabetic rats
by: Ziwei Wang, et al.
Published: (2019-09-01)

OGT-Mediated KEAP1 Glycosylation Accelerates NRF2 Degradation Leading to High Phosphate-Induced Vascular Calcification in Chronic Kidney Disease
by: Tian-Hua Xu, et al.
Published: (2020-10-01)

Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis
by: Áislan de Carvalho Vivarini, et al.
Published: (2017-09-01)

Effect of Pingchuan Guben decoction on inflammatory factor and protease molecule synthesis and Keap1-Nrf2-ARE pathway function in patients with stable COPD
by: Chun-Hong Duan
Published: (2016-05-01)

The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment
by: Keiko Taguchi, et al.
Published: (2021-12-01)

Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction
by: Barbara Cosimelli, et al.
Published: (2019-01-01)

Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer
by: Pelin Telkoparan-Akillilar, et al.
Published: (2021-03-01)

Nrf2 in cancers: A double‐edged sword
by: Shijia Wu, et al.
Published: (2019-05-01)

Nuclear Factor Erythroid 2 Activation Mediated by PRKCA in Increasing Ca2+ Intracellular in Diabetic Condition
by: Shahdevi Nandar Kurniawan, et al.
Published: (2018-06-01)

Diverging role of Nrf2 in cancer progression and prevention
by: Lokesh Gambhir, et al.
Published: (2015-01-01)

The NRF2/KEAP1 Pathway Modulates Nasopharyngeal Carcinoma Cell Radiosensitivity via ROS Elimination
by: Zhou J, et al.
Published: (2020-09-01)

KEAP1 Is Required for Artesunate Anticancer Activity in Non-Small-Cell Lung Cancer
by: Kristen S. Hill, et al.
Published: (2021-04-01)

A Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2
by: Lu Qiu, et al.
Published: (2018-07-01)

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue
by: Dmitry M. Hushpulian, et al.
Published: (2021-04-01)

Rifampicin attenuated global cerebral ischemia injury via activating the nuclear factor erythroid 2-related factor pathway
by: Beibei Chen, et al.
Published: (2016-11-01)

DJ‐1 plays a neuroprotective role in SH‐SY5Y cells by modulating Nrf2 signaling in response to lidocaine‐mediated oxidative stress and apoptosis
by: Ying Xue, et al.
Published: (2020-08-01)

NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
by: Ángel Cores, et al.
Published: (2020-06-01)

Pharmacological Protection against Ischemia-Reperfusion Injury by Regulating the Nrf2-Keap1-ARE Signaling Pathway
by: Bercis Imge Ucar, et al.
Published: (2021-05-01)

The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants
by: Mi-Kyoung Kwak, et al.
Published: (2010-10-01)