Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

Stress is a major risk for mental illness that is known to impact glutamate function in the medial prefrontal cortex (mPFC). Using magnetic resonance spectroscopy we find evidence for an adaptive mPFC glutamate response to stress in healthy adults that is notably impaired in patients with major depr...

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Bibliographic Details
Main Authors: Jessica A. Cooper, Makiah R. Nuutinen, Victoria M. Lawlor, Brittany A. M. DeVries, Elyssa M. Barrick, Shabnam Hossein, Daniel J. Cole, Chelsea V. Leonard, Emma C. Hahn, Andrew P. Teer, Grant S. Shields, George M. Slavich, Dost Ongur, J. Eric Jensen, Fei Du, Diego A. Pizzagalli, Michael T. Treadway
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23284-9

Internet

https://doi.org/10.1038/s41467-021-23284-9

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