Mechanisms leading to disseminated apoptosis following NMDA receptor blockade in the developing rat brain

Mechanisms leading to disseminated apoptosis following NMDA receptor blockade in the developing rat brain

The developing rodent brain is vulnerable to pharmacological blockade of N-methyl-d-aspartate (NMDA) receptors which can lead to severe and disseminated apoptotic neurodegeneration. Here, we show that systemic administration of the NMDA receptor antagonist MK801 to 7-day-old rats leads to impaired a...

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Bibliographic Details
Main Authors: Henrik H Hansen, Tim Briem, Mark Dzietko, Marco Sifringer, Alexander Voss, Wojciech Rzeski, Barbara Zdzisinska, Friederike Thor, Rolf Heumann, Andrzej Stepulak, Petra Bittigau, Chrysanthy Ikonomidou
Format: Article
Language:English
Published: Elsevier 2004-07-01
Series:Neurobiology of Disease
Subjects:
MK801
NMDA receptor
Apoptosis
Neurodegeneration
Development
BDNF
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104000749

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