Expression of a mutant p53 results in an age-related demographic shift in spontaneous lung tumor formation in transgenic mice.

Expression of a mutant p53 results in an age-related demographic shift in spontaneous lung tumor formation in transgenic mice.

BACKGROUND:Mutations in the P53 gene are among the most common genetic abnormalities in human lung cancer. Codon 273 in the sequence-specific DNA binding domain is one of the most frequently mutated sites. METHODOLOGY:To investigate the role of mutant p53 in lung tumorigenesis, a lung specific p53(2...

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Bibliographic Details
Main Authors: Wenrui Duan, Li Gao, Xin Wu, Erinn M Hade, Jian-Xin Gao, Haiming Ding, Sanford H Barsky, Gregory A Otterson, Miguel A Villalona-Calero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2680060?pdf=render

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http://europepmc.org/articles/PMC2680060?pdf=render

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