The Histone Methyltransferase DOT1L Is a Functional Component of Estrogen Receptor Alpha Signaling in Ovarian Cancer Cells

The Histone Methyltransferase DOT1L Is a Functional Component of Estrogen Receptor Alpha Signaling in Ovarian Cancer Cells

Although a large fraction of high-grade serous epithelial ovarian cancers (OCs) expresses Estrogen Receptor alpha (ERα), anti-estrogen-based therapies are still not widely used against these tumors due to a lack of sufficient evidence. The histone methyltransferase Disruptor of telomeric si...

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Bibliographic Details
Main Authors: Annamaria Salvati, Valerio Gigantino, Giovanni Nassa, Giorgio Giurato, Elena Alexandrova, Francesca Rizzo, Roberta Tarallo, Alessandro Weisz
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
ovarian cancer
erα
dot1l
gene expression
estrogen signaling
targeted therapy
Online Access:https://www.mdpi.com/2072-6694/11/11/1720

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