γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport

γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport

Abstract Background Ceramide synthesis and metabolism is a promising target in cancer drug development. γ-tocotrienol (GT3), a member of the vitamin E family, orchestrates multiple effects that ensure the induction of apoptosis in both, wild-type and RAS-mutated pancreatic cancer cells. Here, we inv...

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Bibliographic Details
Main Authors: Victoria E. Palau, Kanishka Chakraborty, Daniel Wann, Janet Lightner, Keely Hilton, Marianne Brannon, William Stone, Koyamangalath Krishnan
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Cancer
Subjects:
γ-Tocotrienol
Vitamin E
Pancreatic cancer
ARV-1
CERT
Ceramide transport
Online Access:http://link.springer.com/article/10.1186/s12885-018-4462-y

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