Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells

Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells

Qingyihuaji formula (QYHJ), confirmed efficacious in a series of clinical trials, has been applied to human pancreatic carcinoma treatment in Shanghai Cancer Center for years. Recent evidence highlighted that pluripotent stem cells transcription factor Nanog plays a pivotal role in carcinogenesis. H...

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Main Authors: Song Gao, Yan Pan, Libin Song, Lei Dong, Lao I. Weng, Peng Wang, Yongqiang Hua, Zhen Chen, Luming Liu
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2016/7028289
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spelling doaj-f743bc5d2937450ebc831d09f0c832562020-11-24T21:52:53ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882016-01-01201610.1155/2016/70282897028289Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem CellsSong Gao0Yan Pan1Libin Song2Lei Dong3Lao I. Weng4Peng Wang5Yongqiang Hua6Zhen Chen7Luming Liu8Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaDepartment of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaDepartment of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaDepartment of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaDepartment of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaDepartment of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaDepartment of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaQingyihuaji formula (QYHJ), confirmed efficacious in a series of clinical trials, has been applied to human pancreatic carcinoma treatment in Shanghai Cancer Center for years. Recent evidence highlighted that pluripotent stem cells transcription factor Nanog plays a pivotal role in carcinogenesis. However, there is little published information regarding the underlying clinical significance and mechanisms of transcription factor Nanog in pancreatic cancer. In this study, our results indicated that Nanog is overexpressed in human pancreatic cancer stem cells and downregulated by QYHJ, which may contribute to explain the clinical effectiveness of QYHJ and provide advanced pancreatic cancer patients with a new therapeutic option, supporting our hypothesis that the degradation pathway is another mechanism by which QYHJ affects Nanog expression.http://dx.doi.org/10.1155/2016/7028289
collection DOAJ
language English
format Article
sources DOAJ
author Song Gao
Yan Pan
Libin Song
Lei Dong
Lao I. Weng
Peng Wang
Yongqiang Hua
Zhen Chen
Luming Liu
spellingShingle Song Gao
Yan Pan
Libin Song
Lei Dong
Lao I. Weng
Peng Wang
Yongqiang Hua
Zhen Chen
Luming Liu
Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells
Evidence-Based Complementary and Alternative Medicine
author_facet Song Gao
Yan Pan
Libin Song
Lei Dong
Lao I. Weng
Peng Wang
Yongqiang Hua
Zhen Chen
Luming Liu
author_sort Song Gao
title Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells
title_short Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells
title_full Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells
title_fullStr Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells
title_full_unstemmed Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells
title_sort nanog predicts poor prognosis in human pancreatic cancer and is downregulated by qingyihuaji formula in pancreatic cancer stem cells
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2016-01-01
description Qingyihuaji formula (QYHJ), confirmed efficacious in a series of clinical trials, has been applied to human pancreatic carcinoma treatment in Shanghai Cancer Center for years. Recent evidence highlighted that pluripotent stem cells transcription factor Nanog plays a pivotal role in carcinogenesis. However, there is little published information regarding the underlying clinical significance and mechanisms of transcription factor Nanog in pancreatic cancer. In this study, our results indicated that Nanog is overexpressed in human pancreatic cancer stem cells and downregulated by QYHJ, which may contribute to explain the clinical effectiveness of QYHJ and provide advanced pancreatic cancer patients with a new therapeutic option, supporting our hypothesis that the degradation pathway is another mechanism by which QYHJ affects Nanog expression.
url http://dx.doi.org/10.1155/2016/7028289
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AT yanpan nanogpredictspoorprognosisinhumanpancreaticcancerandisdownregulatedbyqingyihuajiformulainpancreaticcancerstemcells
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AT leidong nanogpredictspoorprognosisinhumanpancreaticcancerandisdownregulatedbyqingyihuajiformulainpancreaticcancerstemcells
AT laoiweng nanogpredictspoorprognosisinhumanpancreaticcancerandisdownregulatedbyqingyihuajiformulainpancreaticcancerstemcells
AT pengwang nanogpredictspoorprognosisinhumanpancreaticcancerandisdownregulatedbyqingyihuajiformulainpancreaticcancerstemcells
AT yongqianghua nanogpredictspoorprognosisinhumanpancreaticcancerandisdownregulatedbyqingyihuajiformulainpancreaticcancerstemcells
AT zhenchen nanogpredictspoorprognosisinhumanpancreaticcancerandisdownregulatedbyqingyihuajiformulainpancreaticcancerstemcells
AT lumingliu nanogpredictspoorprognosisinhumanpancreaticcancerandisdownregulatedbyqingyihuajiformulainpancreaticcancerstemcells
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