Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles

Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles

Abstract Background Endosomal trafficking and amyloidogenic cleavage of amyloid precursor protein (APP) is believed to play a role in the neurodegeneration observed in Alzheimer’s disease (AD). Recent evidence has suggested that packaging and secretion of APP and its amyloidogenic cleaved products i...

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Bibliographic Details
Main Authors: Allaura S. Cone, Stephanie N. Hurwitz, Gloria S. Lee, Xuegang Yuan, Yi Zhou, Yan Li, David G. Meckes
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Molecular and Cell Biology
Subjects:
Extracellular vesicle
Exosomes
Alzheimer dementia
Neurodegeneration
Multivesicular bodies
Protein trafficking
Online Access:http://link.springer.com/article/10.1186/s12860-020-00302-0

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http://link.springer.com/article/10.1186/s12860-020-00302-0

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