The Mechanisms of the Anti-Inflammatory and Anti-Apoptotic Effects of Omega-3 Polyunsaturated Fatty Acids during Methotrexate-Induced Intestinal Damage in Cell Line and in a Rat Model

The Mechanisms of the Anti-Inflammatory and Anti-Apoptotic Effects of Omega-3 Polyunsaturated Fatty Acids during Methotrexate-Induced Intestinal Damage in Cell Line and in a Rat Model

<i>Background:</i> The aim of this study was to examine the anti-inflammatory and anti-apoptotic patterns of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during methotrexate (MTX) induced intestinal damage in cell culture and in a rat model. <i>Methods:</i> Non-treated and...

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Bibliographic Details
Main Authors: Tal Koppelmann, Yulia Pollak, Yoav Ben-Shahar, Gregory Gorelik, Igor Sukhotnik
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Nutrients
Subjects:
chemotherapy
intestine
mucositis
TNF-α
NF-κB
COX-2
Online Access:https://www.mdpi.com/2072-6643/13/3/888

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