Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.

Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.

The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss. By means of long-term two-photon in vivo imaging and confocal imaging, we characterized the spatio-temporal pattern of de...

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Bibliographic Details
Main Authors: Tobias Bittner, Martin Fuhrmann, Steffen Burgold, Simon M Ochs, Nadine Hoffmann, Gerda Mitteregger, Hans Kretzschmar, Frank M LaFerla, Jochen Herms
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2982845?pdf=render

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