SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress.

SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress.

Parkinson's disease (PD) is an incurable age-related neurodegenerative disorder affecting both the central and peripheral nervous systems. Although common, the etiology of PD remains poorly understood. Genetic studies infer that the disease results from a complex interaction between genetics an...

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Bibliographic Details
Main Authors: Blake Byers, Branden Cord, Ha Nam Nguyen, Birgitt Schüle, Lief Fenno, Patrick C Lee, Karl Deisseroth, J William Langston, Renee Reijo Pera, Theo D Palmer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3217921?pdf=render

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