HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge

HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge

Before ovulation, a surge of luteinizing hormone (LH) triggers the resumption of meiosis in oocytes, which is mediated by EGF-like growth factors. Here, the authors show that HDAC3 inhibits mouse oocyte maturation by negatively regulating the expression of EGF-like factor before the LH surge.

Bibliographic Details
Main Authors: Huarong Wang, Han Cai, Xiao Wang, Meiling Zhang, Bingying Liu, Ziqi Chen, Tingting Yang, Junshun Fang, Yanhao Zhang, Wei Liu, Jun Han, Qirui Guo, Hua Zhang, Haibin Wang, Guoliang Xia, Chao Wang
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13671-8

Internet

https://doi.org/10.1038/s41467-019-13671-8

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