A perfect correlate does not a surrogate make

<p>Abstract</p> <p>Background</p> <p>There is common belief among some medical researchers that if a potential surrogate endpoint is highly correlated with a true endpoint, then a positive (or negative) difference in potential surrogate endpoints between randomization g...

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Bibliographic Details
Main Authors: Kramer Barnett S, Baker Stuart G
Format: Article
Language:English
Published: BMC 2003-09-01
Series:BMC Medical Research Methodology
Online Access:http://www.biomedcentral.com/1471-2288/3/16