A Synthetic Nanoparticle Based Vaccine Approach Targeting MSP4/5 Is Immunogenic and Induces Moderate Protection Against Murine Blood-Stage Malaria

A Synthetic Nanoparticle Based Vaccine Approach Targeting MSP4/5 Is Immunogenic and Induces Moderate Protection Against Murine Blood-Stage Malaria

Malaria remains a significant health problem in many tropical and sub-tropical regions. The development of vaccines against the clinically active blood-stage of infection needs to consider variability and polymorphism in target antigens, and an adjuvant system able to induce broad spectrum immunity...

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Bibliographic Details
Main Authors: Kirsty L. Wilson, Dodie Pouniotis, Jennifer Hanley, Sue D. Xiang, Charles Ma, Ross L. Coppel, Magdalena Plebanski
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
blood-stage
malaria
nanoparticles
adjuvant
immunogenicity
protection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00331/full

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