The correlation between serum MR-proANP and neurohumoral system change in patients with acute myocardial infarction

• Main Author: Jing-Wen Xia
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Acute myocardial infarction Midregional pro-atrial natriuretic peptide Renin-angiotensin-aldosterone Myocardial remodeling
• Online Access: http://www.hnykdxxb.com/PDF/201708/9.pdf

Objective: To study the correlation between serum midregional pro-atrial natriuretic peptide (MR-proANP) and neurohumoral system change in patients with acute myocardial infarction (AMI). Methods: A total of 56 patients who were diagnosed with acute myocardial infarction in our hospital between May 2013 and December 2015 were selected as the AMI group, 45 patients with stable angina pectoris who were treated during the same period were selected as the SAP group, and 60 healthy volunteers who received physical examination during the same period were selected as the control group. Serum was collected to determine the levels of MR-proANP, neurohumor-related hormones and myocardial remodeling-related molecules. Results: Serum MR-proANP, NE, E, PRA, Ang-II, ALD, MMP2, MMP10, PICP and PIIINP levels of AMI group were significantly higher than those of SAP group and control group; serum NE, E, PRA, Ang-II, ALD, MMP2, MMP10, PICP and PIIINP levels in AMI group of patients with high MR-proANP levels were significantly higher than those in AMI group of patients with low MR-proANP levels. Conclusions: Serum MR-proANP significantly increases in patients with AMI and is closely related to the degree of compensatory neurohumoral change and myocardial remodeling.