TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis.

TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis.

In vertebrate definitive hematopoiesis, nascent hematopoietic stem/progenitor cells (HSPCs) migrate to and reside in proliferative hematopoietic microenvironment for transitory expansion. In this process, well-established DNA damage response pathways are vital to resolve the replication stress, whic...

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Bibliographic Details
Main Authors: Lei Gao, Dantong Li, Ke Ma, Wenjuan Zhang, Tao Xu, Cong Fu, Changbin Jing, Xiaoe Jia, Shuang Wu, Xin Sun, Mei Dong, Min Deng, Yi Chen, Wenge Zhu, Jinrong Peng, Fengyi Wan, Yi Zhou, Leonard I Zon, Weijun Pan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4488437?pdf=render

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