A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv “Click Chemistry” targeted to αvβ3 integrin for therapy

<p>Clinical experiences often document, that a successful tumor control requires high doses of drug applications. It is widely believed that unavoidable adverse reactions could be minimized by using gene-therapeutic strategies protecting the tumor-surrounding healthy tissue as well as the bone...

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Bibliographic Details
Main Author: Klaus Braun, Manfred Wiessler, R&#252;diger Pipkorn, Volker Ehemann, Tobias B&#228;uerle, Heinz Fleischhacker, Gabriele M&#252;ller, Peter Lorenz, Waldemar Waldeck
Format: Article
Language:English
Published: Ivyspring International Publisher 2010-01-01
Series:International Journal of Medical Sciences
Online Access:http://www.medsci.org/v07p0326.htm