Critical role of CD4+ T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection

Critical role of CD4+ T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection

Characterization of protective immunity to Zika virus has largely focussed on CD8+ T cells and antibody-mediated protection. Here the authors show roles for CD4+ T cells and the associated IFNγ signaling in antibody-mediated resistance to Zika virus infection.

Bibliographic Details
Main Authors: Carolina G. O. Lucas, Jamil Z. Kitoko, Fabricio M. Ferreira, Vinicius G. Suzart, Michelle P. Papa, Sharton V. A. Coelho, Cecilia B. Cavazzoni, Heitor A. Paula-Neto, Priscilla C. Olsen, Akiko Iwasaki, Renata M. Pereira, Pedro M. Pimentel-Coelho, Andre M. Vale, Luciana B. de Arruda, Marcelo T. Bozza
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05519-4

Internet

https://doi.org/10.1038/s41467-018-05519-4

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