A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction
KLF family transcription factors (KLFs) regulate many cellular processes, including proliferation, survival and stress responses. Here, the authors position KLFs as important regulators of autophagy and lifespan in C. elegans, a role that may extend to the modulation of age-associated vascular pheno...
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Nature Publishing Group
2017-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00899-5 |
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doaj-f6fefca5fe574b6cb4028da608dba5602021-05-11T07:02:23ZengNature Publishing GroupNature Communications2041-17232017-10-018111210.1038/s41467-017-00899-5A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunctionPaishiun N. Hsieh0Guangjin Zhou1Yiyuan Yuan2Rongli Zhang3Domenick A. Prosdocimo4Panjamaporn Sangwung5Anna H. Borton6Evgenii Boriushkin7Anne Hamik8Hisashi Fujioka9Ciaran E. Fealy10John P. Kirwan11Maureen Peters12Yuan Lu13Xudong Liao14Diana Ramírez-Bergeron15Zhaoyang Feng16Mukesh K. Jain17Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityDepartment of Pharmacology, Case Western Reserve UniversityDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityElectron Microscopy FacilityDepartment of Biomedical Sciences, Kent State UniversityDepartment of Pathobiology, Lerner Research InstituteDepartment of Biology, Oberlin CollegeDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityDepartment of Pharmacology, Case Western Reserve UniversityDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve UniversityKLF family transcription factors (KLFs) regulate many cellular processes, including proliferation, survival and stress responses. Here, the authors position KLFs as important regulators of autophagy and lifespan in C. elegans, a role that may extend to the modulation of age-associated vascular phenotypes in mammals.https://doi.org/10.1038/s41467-017-00899-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Paishiun N. Hsieh Guangjin Zhou Yiyuan Yuan Rongli Zhang Domenick A. Prosdocimo Panjamaporn Sangwung Anna H. Borton Evgenii Boriushkin Anne Hamik Hisashi Fujioka Ciaran E. Fealy John P. Kirwan Maureen Peters Yuan Lu Xudong Liao Diana Ramírez-Bergeron Zhaoyang Feng Mukesh K. Jain |
| spellingShingle |
Paishiun N. Hsieh Guangjin Zhou Yiyuan Yuan Rongli Zhang Domenick A. Prosdocimo Panjamaporn Sangwung Anna H. Borton Evgenii Boriushkin Anne Hamik Hisashi Fujioka Ciaran E. Fealy John P. Kirwan Maureen Peters Yuan Lu Xudong Liao Diana Ramírez-Bergeron Zhaoyang Feng Mukesh K. Jain A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction Nature Communications |
| author_facet |
Paishiun N. Hsieh Guangjin Zhou Yiyuan Yuan Rongli Zhang Domenick A. Prosdocimo Panjamaporn Sangwung Anna H. Borton Evgenii Boriushkin Anne Hamik Hisashi Fujioka Ciaran E. Fealy John P. Kirwan Maureen Peters Yuan Lu Xudong Liao Diana Ramírez-Bergeron Zhaoyang Feng Mukesh K. Jain |
| author_sort |
Paishiun N. Hsieh |
| title |
A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| title_short |
A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| title_full |
A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| title_fullStr |
A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| title_full_unstemmed |
A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| title_sort |
conserved klf-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-10-01 |
| description |
KLF family transcription factors (KLFs) regulate many cellular processes, including proliferation, survival and stress responses. Here, the authors position KLFs as important regulators of autophagy and lifespan in C. elegans, a role that may extend to the modulation of age-associated vascular phenotypes in mammals. |
| url |
https://doi.org/10.1038/s41467-017-00899-5 |
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