Gender-Related Response of Body Systems in COVID-19 Affects Outcome

• Main Authors: M. Khaksari, N. Sabet, Z. Soltani, H. Bashiri
• Format: Article
• Language: Russian
• Published: Sankt-Peterburg : NIIÈM imeni Pastera 2019-06-01
• Series: Infekciâ i Immunitet
• Subjects: coronavirus disease 2019, gender difference, inflammation, angiotensin-converting enzyme 2, estrogen, progesterone
• Online Access: https://www.iimmun.ru/iimm/article/view/1664
• ISSN: 2220-7619; 2313-7398

Severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) is the seventh member of the coronaviruses (CoVs) family that infects humans and causes coronavirus disease 2019 (COVID-19), which is currently a global pandemic. Widespread secretion of cytokines has been shown to occur early in severe cases of the disease and can be an effective factor in the rapid progression of the disease. The storm of cytokines including interleukin (IL)-1β, IL-2, IL-7, IL-6, IL-8, IL-10, IL-17, and gamma interferon (INF-ɣ) has been reported in several organ failures. Systemic inflammation indicates an advanced stage of acute disease, which is characterized by multiple organ failure and elevated key inflammatory markers. The important disturbances in the various body systems such as alveolar damage and pulmonary edema in the lung, increase of liver enzymes in the liver, decrease of microbiota and increase of mesenteric edema in the gastrointestinal system, increase of blood urea nitrogen (BUN), creatinine (Cr) and glomerular filtration rate (GFR) in the kidney, myocardial dysfunction, arrhythmia and cardiac enzymes elevation in the heart, blood brain barrier (BBB) disruption, brain edema and encephalopathy in the brain have been reported. Studies have shown a gender difference between the incidence and mortality of COVID-19. In this review, we investigated the gender difference in the systemic effects of COVID-19 and found that this gender difference exists especially in the respiratory, cardiovascular, liver, gastrointestinal and kidney systems. Due to the worse outcome of COVID in males, the role of female sex hormones in causing these gender differences is noticeable. There can be a systemic and local effect of female sex hormones, especially estrogen and possibly progesterone, on various cells. Among the effects of these hormones is the regulation of localized angiotensin-converting enzyme 2 (ACE2) levels. ACE2 is the route of entry for SARS-CoV-2 virus into the cell. It is hoped that this review would address gender differences for better management of COVID-19 treatment.