Functional validation of the albinism-associated tyrosinase T373K SNP by CRISPR/Cas9-mediated homology-directed repair (HDR) in rabbitsResearch in context

Functional validation of the albinism-associated tyrosinase T373K SNP by CRISPR/Cas9-mediated homology-directed repair (HDR) in rabbitsResearch in context

Background: Oculocutaneous albinism (OCA) is a group of autosomal recessive disorders characterized by reduced melanin that are caused by mutations in the gene encoding tyrosinase (TYR), which is the rate-limiting enzyme in the production of the pigment melanin. Many studies or meta-analyses have su...

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Bibliographic Details
Main Authors: Yuning Song, Yuxin Zhang, Mao Chen, Jichao Deng, Tingting Sui, Liangxue Lai, Zhanjun Li
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418303992

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