Crystal Structural Analysis of DL-Mandelate Salt of Carvedilol and Its Correlation with Physicochemical Properties

Crystal Structural Analysis of DL-Mandelate Salt of Carvedilol and Its Correlation with Physicochemical Properties

A 1:1 salt of carvedilol (CVD), an anti-hypertensive drug, with DL-mandelic acid (DL-MA) was crystallized from ethanol and the structure was characterized by X-ray single-crystal diffraction, revealing salt formation by transfer of an acidic proton from the COOH group of MA to the aliphatic (acyclic...

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Bibliographic Details
Main Authors: Nanami Hata, Takayuki Furuishi, Majid I. Tamboli, Momiji Ishizaki, Daiki Umeda, Kaori Fukuzawa, Etsuo Yonemochi
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Crystals
Subjects:
carvedilol
dl-mandelic acid
salt
crystal structure
solubility
Online Access:https://www.mdpi.com/2073-4352/10/1/53

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